His artistic works combine the narrative and the surreal through subtle imagery, which are created within the framework of video art, art film and dance. His artistic compositions are often inspired by the specific selection of architecturally or scenically significant sites.

For his film creations Karsten Liske collaborated with composers Jóhann Jóhannsson, Rabih Abou-Khalil, Edgardo Rudnitzky and the performers Erna Ómarsdóttir, Davide Camplani, Claudia de Serpa Soares and Ayten Uncuoğlu.

His works also include several cinematographic recordings of opera and dance productions from Sasha Waltz and Sidi Larbi Cherkaoui on behalf of Théâtre Royal La Monnaie Brussels and sasha waltz & guests in Berlin.

Among collaborators were Goethe Institutes in Montreal, Rome, Istanbul and Tel Aviv and seven years film in Berlin.